Table 2.

Effect of urea on Aβ aggregate size

	Urea concentration
	0.4 M	2 M	4 M	6 M
〈M〉w (kDa)	1100 ± 110	100 ± 20	32 ± 2	14 ± 2
Magg(kDa)a	3000 ± 300	270 ± 40	160 ± 10	63 ± 9
〈Rg2〉1/2z (nm)	56 ± 8	96 ± 22	50 ± 12	37 ± 12
Lc(nm)	150 ± 5	290 ± 30	NDc	ND
dagg(nm)b	6.8	ND	ND	ND

^a We assumed only monomer, dimer, and large aggregates to be present. Then, M_agg = (〈Μ〉_w− W_monomerM_monomer − W_dimerM_dimer)/w_agg.

^b Calculated from M_agg, L_c, and assumed specific volume of hydrated peptide.

^c ND, not determined.