Table 3.
Summary of experimental results
Urea conc. | θ217 (CD) | % Aggregate (SEC) | Average no. of monomers in aggregates (LS) | Growth over time? (LS) | Aggregate morphology (AFM) |
0.4 M | −2058 | 37 | 700 | Yes | Fibrillar: 50–150 nm long, 6–7 nm high |
2 M | −1674 | 37 | 65 | Slight | Mixed: |
Globular: 6–7 nm high | |||||
Fibrillar: 200–700 nm long, 8–12 nm high | |||||
4 M | −1419 | 20 | 35 | No | Globular: 1–2 nm high |
6 M | −1135 | 22 | 15 | No | Globular: 1–2 nm high |