Table 4.

The summary favorable or unfavorable effect of features from position P1 to P9 in TAP binders

	Peptide positions
Features	P1	P2	P3	P4	P5	P6	P7	P8	P9
Volume	−	++	++				++		++
Charge	++	++					++		++
Aromatic	−		++				++		++++
Hydrophobic	−	−	++				++		++
Hydrophilic	++	++	−				−		−
Hydropathy		−					++
Accessibility		++	++						++
Flexibility		++	−				−
% buried residues		−					++		−

++ and − illustrates positive and negatives effect of features at specific position in TAP binding affinity of peptides.