Table 1.

Conservation of the VHL residues, found in tumors

First column, residues in human VHL, which were found in the VHL-associated tumors; second through sixth columns, conservation of the residues in the correspondingly indicated species; seventh column, major or minor tumor mutant hotspot; eighth column possible (?) or proved function of the region, in which the residue is located; bottom of the table, % conservation of the protein in lower species, % conservation of the tumorigenic hotspots in lower species, and % conservation of the rest of the protein in lower species. Conserved residues, purple; not conserved, yellow; missing residues, blue.