Table 2.

VHL-binding protein orthologs in lower species

Organism	LON ortholog	MetAP-2	Elongin C	HIF-1α
Homo sapiens	present	present	present	full length
Xenopus tropicalis	present	present	present	full length
Takifugu rubripes	fused to VHL	present	2 separate polypep.	short
Drosophila melanogaster	not present	present	present	short
Anopheles gambiae	not present	present	present	short
Caenorhabditis briggsae	not present	present	present	short
Caenorhabditis elegans	not present	present	present	short

First column indicates corresponding organisms, in which VHL homolog was found; second column represents presence or absence of the single-domain LON protease orthologs in the corresponding organisms; third column indicates presence or absence of the MetAP-2; fourth column indicates presence of the Elongin C ortholog; and, finally, fifth column indicates presence of the HIF-1α protein and its length.