Table 2.

Interactions in the complex and buried surface area

CDR178	Residues contacted in TaqP†	Number of van der Waals contacts (Number of H-bonds)	Buried surface area, Å2‡
L1 (Y32 Y34)	Y545 P548 D547	5  (1)	41
L2 (D50 L54 G56)	E471 R536 I546	3  (3)	83
L3 (S91 S92)	R313 K314	2  (2)	64
H1	None	0  (0)	9
H2 (S53 T55 T56 D57 K63 S64)	S383 T385 T386 E388 E397 W398 A568 A570 R728	10  (15)	184
H3 (G98 Y99 W100 Y101)	S515 K542 S543 Y545 N580	15  (4)	128
FRAME (L46L Y49L V58L W105H)	P481 L484 N485 K511 R512 T544 Y545	8  (3)	305
All		43  (28)	814

¹⁷⁸Numbered according to Kabat (24). Residues making contacts are in parentheses. 

^†Residues shown to contact DNA in a TaqP–DNA complex (6) are shown in bold type. 

^‡Calculated by using a 1.6-Å probe radius.