Table 2.

Incidence of amenorrhea

	6FEC 100	3FEC/3D
Amenorrhea at the end of chemotherapy	78 (93 %)	65 (92.8 %)
Clinically reversible amenorrhea (n = 154)
Total population**	20/84 (23.7 %)	25/70 (35.5 %)
Patients < 40 years (39)	13/18 (72 %)	15/21 (71.4 %)
Patients ≥ 40 years (115)**	7/66 (10.5 %)	10/49 (20.5 %)
Recovery of premenopausal hormone values *
Total population (n = 101)**	18/59 (29 %)	18/42 (42 %)
Patients < 40 years (31)	11/15 (73.3 %)	12/16 (75 %)
Patients ≥ 40 years (70)**	6/42 (14 %)	6/28 (21.4 %)
Clinically reversible amenorrhea. No hormone values available (n = 53)
Patients < 40 years (8)	2/3 (66 %)	3/5 (60 %)
Patients ≥ 40 years (45)**	1/24 (4 %)	4/21 (19 %)

*within a year after the end of chemotherapy

** p < 0.05, chi-square