Figure 1.

Examples of β-catenin phenotypes detected in human hepatocellular carcinomas. A: Magnification of the squared area seen in 'D' with β-catenin located in the cytoplasm and also in several nuclei (arrowheads). B: Tumor with normal confinement of β-catenin to the cell membrane and C: cytoplasmic staining of β-catenin without detectable expression in the nuclei. D and E: serial sections of an HCC expressing glutamine synthetase (E) and nuclear β-catenin (D). Original magnification: 400× (A, B, C) and 100× (D, E). The mutation of β-catenin in the serial sections was S33C.