Table 1.

Settings for Positive End-Expiratory Pressure (PEEP), According to the Required Fraction of Inspired Oxygen (FiO₂).^*

FiO2	PEEP
0.3	5
0.4	5–8
0.5	8–10
0.6	10
0.7	10–14
0.8	14
0.9	14–18
1.0	18–24

^*Settings are from the ARDSNet trial.¹⁹ The required FiO₂ is the lowest value that maintains arterial oxyhemoglobin saturation above 90%. After the corresponding level of PEEP is selected, arterial oxyhemoglobin saturation and plateau airway pressure should be monitored in the patient.