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. Author manuscript; available in PMC: 2008 Sep 1.
Published in final edited form as: Immunity. 2008 Feb 28;28(3):324–334. doi: 10.1016/j.immuni.2008.01.008

Figure 3. IAb/3K atom to atom contacts with the TCRs and the correlation with IAb/3K mutational data.

Figure 3

The figure shows the number of atom to atom contacts between the A) B3K506, B) 2W20 or C) YAe62 TCR and individual IAb/3K amino acids within the α chain (cyan), β chain (magenta) and peptide (yellow) portion of the ligand. Data are shown for all IAb/3K amino acids that contact the TCR in any of the structures. The IAb/3K non-alanine amino acids that were previously (Huseby et al., 2006) subjected to mutational analysis are high-lighted with a rectangle. A green rectangle indicates that when this position was mutated to alanine and tested for TCR binding there was an increase in ΔΔG of ≤ 0.8 kcal/mole. A red rectangle indicates an increase of >0.8 kcal/mole.