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. 2008 Apr 7;181(1):27–35. doi: 10.1083/jcb.200801096

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Copyright © 2008, The Rockefeller University Press

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Figure 2. — Nuclear architecture alterations in hair follicle stem cells of Zmpste24^−/− mice. (A) Distribution of nuclear heterochromatin and 5mC. (B) Chromocenter quantification in hair follicles from the indicated mice. Cells with nuclear aberrations related to apoptosis were excluded from analysis. 100 cells of each region in three animals per genotype were examined. *, P < 0.05. Error bars represent SEM. (C) Immunoblot analysis of lamin A/C in the epidermis of Zmpste24^+/+ and Zmpste24 ^−/− animals. Results are representative of three different experiments. (D) Immunolocalization of pre–lamin A in tail skin hair follicles from Zmpste24^+/+ and Zmpste24 ^−/− mice. (E) Detailed view of the distribution of lamin A and pre–lamin A in hair follicles from Zmpste24^+/+ and Zmpste24 ^−/− animals. Bars: (A) 10 μm; (D) 100 μm; (E) 50 μm.