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. 2008 Apr 7;181(1):27–35. doi: 10.1083/jcb.200801096

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Copyright © 2008, The Rockefeller University Press

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Figure 3. — Zmpste24 deficiency reduces the proliferative potential of epidermal stem cells. (A) Quantification of size and number of macroscopic colonies obtained from isolated epidermal cells purified from skin from newborn and adult mice. (B) Localization of cells undergoing DNA replication by short-term BrdU labeling in hair follicles of the indicated mice treated or not treated with TPA, and quantification of DNA-replicating cells in the bulge region. (C) Detection of cells showing DNA fragmentation by TUNEL assays in hair follicles from the indicated mice, and quantification of TUNEL-positive cells in the hair bulb region of hair follicles treated or not treated with TPA. Boxed areas are magnified in the bottom panels. *, P < 0.05; **, P < 0.01. Error bars represent SEM. Bars: (B and C, top) 100 μm; (C, bottom) 10 μm.