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Characteristics of target lines
| Line | Basal PrP-A expression, %* | Induction by tTA
|
|
|---|---|---|---|
| Fibroblasts | Tg mice | ||
| tetO-PrP/E6539 | <1 | ++ | − |
| tetO-PrP/E6550 | 25–50 | ++++ | +++ |
| tetO-PrP/E6725 | 10 | ++ | ND |
| tetO-PrP/E6740 | 10 | ++++ | ++ |
| tetO-PrP/E7655 | 2 | ++ | + |
ND, not determined.
Expression levels reported were standardized by using FVB PrPC levels as 100%
