Figure 4.

Coverage of FGF-2 models by (A) lysine-specific and (B) di-sulfide cross-linking experiments planned by XlinkPlan, as a function of desired discriminability Δ. (A) The set of N (from 1 to 5) experiments planned by XlinkPlan involving five commercially available cross-linkers was planned using Δ of 3 (solid line), 6 (dashed line), or 12 (dotted line). The coverage at the chosen discriminability is indicated for each set of experiments. (B) The XlinkPlan set of N (from 1 to 50) disulfide trapping experiments was planned using Δ of 1 (solid line), 2 (dashed line), or 4 (dotted line), and an ambiguity region of 9–21 Å.