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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Cell Calcium. 2007 Aug 15;43(4):334–343. doi: 10.1016/j.ceca.2007.06.004

Figure 1. Expression of G573C and G573S mutant of TRPV3 in mammalian cells causes cell death.

Figure 1

T-Rex293 cells transfected with GFP-TRPV3 wild type (V3WT) and the mutants (V3G573C and V3G573S) in pcDNA4/TO vector were treated or not with 20 ng/ml doxycycline. Bright field (middle) and fluorescence (sides) images were taken at 26 hrs. Fluorescence images were taken using the same exposure time, gain and other camera settings. Substantial cell death (round-up cells) is seen in both the G573C and G573S expressing cells treated with doxycycline. Only few dead cells are present in untreated cells and cells expressing V3WT.

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