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. 2008 Apr;10(4):389–398. doi: 10.1593/neo.07856

Figure 4.

Figure 4

Quantification and kinetics of in vivo targeting characteristics of NIR probes in MDA-MB-231, MDA-MB-435, and MCF-7 tumor-bearing SCID mice. (A) Time course of in vivo fluorescence intensities in three different types of breast tumor xenografts measured as units of p/s/cm2/sr. Near-infrared probes were intravenously injected with a dosage of 100 nmol/mouse. t1/2 represents the time at which the tumoral fluorescence intensity has decreased to half of its maximum value. (B) Time course of T/N calculated for the three types of breast tumor xenografts after intravenous injection of IR-1, IR-2, or IR-15 (100 nmol/mouse). T/N values were normalized to preinjection background levels measured before NIR probe injection. Data are expressed as mean ± SD (n = 3 mice per group).