Table 3.

In Vitro Magnetic Resonance Spectroscopy of HT29 Tumor Extracts Following Vehicle and LAQ824 Treatment.

Metabolites (µmol/g wet weight)	Control (N = 5)	LAQ824 (N = 5)	P†
(A) Phosphorus MRS
PE	1.13 ± 0.20	1.85 ± 0.09	.02
PC	1.87 ± 0.21	2.72 ± 0.21	.04
GPE	1.66 ± 0.44	0.49 ± 0.10	.05
GPC	2.34 ± 0.33	0.81 ± 0.08	.01
Pi	5.01 ± 0.91	9.00 ± 1.23	.06
(B) Proton MRS
PC	1.76 ± 0.16	2.51 ± 0.25	.04
GPC	2.05 ± 0.23	1.26 ± 0.13	.02
Free choline	0.16 ± 0.03	0.49 ± 0.08	.01
Leucine	0.23 ± 0.03	0.41 ± 0.08	.005
Iso-leucine	0.11 ± 0.02	0.22 ± 0.02	.005
Valine	0.26 ± 0.04	0.39 ± 0.04	.04
Glutamate	2.05 ± 0.35	0.97 ± 0.09	.04
Glutamine	0.88 ± 0.11	0.44 ± 0.12	.03
PCr + Cr	5.19 ± 0.70	2.40 ± 0.99	.05
Glucose	0.95 ± 0.06	0.37 ± 0.08	.001
Lactate	6.84 ± 0.79	5.80 ± 2.24	NS
Alanine	1.82 ± 0.26	2.05 ± 0.10	NS
Taurine	6.91 ± 0.82	5.17 ± 0.42	NS
Glycine	1.46 ± 0.18	1.23 ± 0.05	NS

Data are expressed as mean ± SEM.

PE indicates phosphoethanolamine; PC, phosphocholine; GPE, glycerophosphoethanolamine; GPC, glycerophosphocholine; PCr, phosphocreatine; Cr, creatine; Pi, inorganic phosphate; NS, not statistically significant (P > .1).

^†Two-tailed unpaired t test was used to compare changes between the vehicle- and LAQ824-treated groups.