Table 1.
Characteristic | Mean ± SD or % |
---|---|
Age at baseline (yr) | 73.6 ± 2.7 |
Gender (men) | 55.4% |
Race (white) | 52.9% |
Weight (kg) | 80.7 ± 14.6 |
Body mass index (kg/m2) | 28.8 ± 4.5 |
Duration of diabetes (yr) † | 12.8 ± 12.4 |
Hemoglobin A1C (%) | 7.6 ± 1.6 |
Insulin use | 14.1% |
Among those who were not using insulin: | |
Sulfonylurea use | 40.7% |
Metformin use | 9.7% |
Thiazolidinedione use | 1.3% |
No hypoglycemic medication use | 57.4% |
Peripheral nerve function | |
Loss of light touch discrimination (unable to detect 5.07 monofilament) ‡ | 22.5% |
Peroneal nerve conduction velocity: popliteal fossa–ankle (m/s) ‡ ,# | 41 ± 8 |
Peroneal nerve compound muscle action potential (CMAP) amplitude at popliteal fossa (mV) ‡ ,** | 3.0 ± 1.9 |
Vibration perception threshold (microns) ‡ | 57.8 ± 37.2 |
Vision | |
Corrected visual acuity 20/50 or worse (%)§ | 6.7% |
Poor contrast sensitivity §,∥ | 12.6% |
Poor depth perception §,¶ | 15.2% |
Renal function | |
Cystatin C (mg/L) †† | 1.04 ± 0.27 |
Estimated GFR < 60 mL/min per 1.73 m2 | 18.8% |
Blood pressure | |
Seated systolic BP (mm Hg) | 138 ± 20 |
SBP: Standing-seated (mm Hg) | 2.6 ± 10.6 |
Seated diastolic BP (mm Hg) | 71 ± 11 |
DBP: Standing-seated (mm Hg) | 4.4 ± 9.6 |
N = 446
Excludes those diagnosed at the baseline visit
Measured at Visit 4
Measured at Visit 3
Log contrast sensitivity ≤ 1.3
Worst score (999) on Frisby stereopsis test
NCV <40 m/s is usually considered abnormal (30)
CMAP < 1.5mV is usually considered abnormal (30)
Reference range for 65 years and older: 0.61-1.23 mg/L (31)