Table 1.
Genes with significant evidence of selection in human populations.
| gene | population | p | localized signal (gene(s)) |
|---|---|---|---|
| APC (adenomatous polyposis of colon) | Asian | 0.021 | — |
| BRD1 (bromodomain-containing protein) | European | 0.013 | — |
| CAPON (nitric oxide synthase-1 neuronal) | European | 0.036 | 2 |
| CLDN5 (claudin-5) | European | 0.042 | — |
| DGCR2 (DiGeorge syndrome region gene 2) | Asian | 0.014 | 2 |
| DTNBP1a (dystrobrevin-binding protein 1) | European | 0.003 | 1 |
| DTNBP1a | African | 0.044 | 1 |
| ENTH (epsin 1) | European | 0.027 | 1 |
| ERBB4 (erythroblastic leukaemia oncogene homolog 4) | Asian | 0.044 | 1 |
| GABRA1 (γ-aminobutyric acid receptor) | European | 0.035 | 1 |
| GABRA1 | Asian | 0.050 | 1 |
| GRM3a (glutamate receptor 3) | Asian | 0.005 | 2 |
| PCM1 (pericentriolar material 1) | European | 0.049 | 1 |
| PCM1 | African | 0.044 | 1 |
| PIK3C3 (phosphatidylinositol 3-kinase) | African | 0.037 | 1 |
| SLC6A4 (serotonin transporter) | European | 0.035 | — |
| SLC6A4 | Asian | 0.014 | — |
| SYNGR1 (synaptogyrin) | Asian | 0.031 | — |
a
Association with schizophrenia is especially strong and well replicated. Two genes showing significance in the PAML analyses, NOTCH4 and TNXB, were marginally non-significant in Haplotter analyses (NOTCH4: 0.094 European; TNXB: 0.06 European), and three genes showed marginal non-significance in the Haplotter analysis (HOPA: 0.060 Asian; NOGO: 0.064 African; TPH1: 0.0505 Asian).