Table 3.
Significant maximum-likelihood results in the human and chimpanzee or primate lineages for genes associated with schizophrenia.
| gene | lineage | model | ω (proportion) | λ | −2Δλ | p |
|---|---|---|---|---|---|---|
| AHI1 (Abelson helper integration site 1) | primate | MA MAofix | 14.97 (0.024) | −3512.58−3514.60 | —4.02 | —<0.05 |
| CHRNA7 (cholinergic receptor neuronal nicotinic α7) | primate | MA MAofix | 17.56 (0.002) | −4098.03−4099.89 | —3.72 | —<0.05 |
| CLDN5 (claudin-5) | human–chimpanzee | MA MAofix | 22.91 (0.061) | −1371.13−1373.85 | —5.44 | —<0.05 |
| COMT (catechol-O-methyltransferase) | primate | MA MAofix | 41.58 (0.013) | −2914.90−2918.90 | —8.00 | —<0.01 |
| DISC1a (disrupted in schizophrenia 1) | human–chimpanzee | MA MAofix | 999 (0.006) | −7704.50−7709.90 | —10.88 | —<0.01 |
| DISC1a | primate | MA | 46.90 (0.032) | −7703.50 | — | — |
| MAofix | −7710.10 | 13.2 | <0.01 | |||
| NOTCH4 | primate | MA | 294.83 (0.006) | −16 523.92 | — | — |
| MAofix | −16 526.56 | 5.26 | <0.05 | |||
| PLXNA2 (plexin A2) | human–chimpanzee | MA | 999 (0.001) | −12 045.56 | — | — |
| MAofix | −12 049.12 | 7.13 | <0.05 |
a
Association with schizophrenia is especially strong and well replicated.