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. Author manuscript; available in PMC: 2008 Apr 7.
Published in final edited form as: Mech Ageing Dev. 2007 Mar 25;128(5-6):355–364. doi: 10.1016/j.mad.2007.03.004

Figure 1.

Figure 1

Approximate limit of detection of rapid evolution using our test statistic as a function of sequence length and Ka/Ks ratio. The straight black line represents the Ka/Ks ratio threshold above which a given protein-coding sequence will be detected as undergoing rapid evolution. Sequence length, which may be a single gene or a concatenated sequence of a large group of genes (the average human-chimpanzee gene pair, only including the protein-coding sequence, is approximately 1.4 kb), is plotted on a logarithmic scale. The dotted gray line is the average Ka/Ks ratio for all human-chimpanzee gene pairs (0.23). Ka/Ks ratios assume a constant Ks and a constant proportion of synonymous and nonsynonymous sites in relation to sequence length, both of which were estimated from the average of all human-chimpanzee gene pairs.