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Thrombotic occlusion times after photochemical injury of the carotid artery. HCII+/+ or HCII−/− mice were injected intravenously with saline (none) or purified rHCII (WT, R189H, or K173Q) 15 minutes before injection of rose bengal dye. The dose of rHCII was calculated to achieve a plasma concentration of 0.125 μM. The bars indicate the means plus or minus SD.
