. 2008 Feb 15;111(8):4118–4125. doi: 10.1182/blood-2007-12-127928

Table 1.

Specificities of lyases

Lyase (reference)	Substrate(s)	Glycosidic linkage(s) cleaved
Chondroitin B-lyase (Michelacci et al²¹)	DS	GalNAc4SO₃→IdoA
Chondroitin ABC-lyase (Oike et al²²)	DS, C4S, C6S	GalNAc4SO₃ and/or 6SO₃→UA;GalNAc4SO₃→UA2SO₃
Flavobacterium heparitinase (Linker and Hovingh²³)	HS	GlcNAc6SO₃→UA;GlcNSO₃→UA;GlcNSO₃6SO₃→UA

C4S indicates chondroitin 4-sulfate; C6S, chondroitin 6-sulfate; GalNAc4SO₃, N-acetylgalactosamine 4-O-sulfate; GlcNAc6SO₃, N-acetylglucosamine 6-O-sulfate; GlcNSO₃, N-sulfoglucosamine; GlcNSO₃6SO₃, N-sulfoglucosamine 6-O-sulfate; IdoA, iduronic acid; and UA, hexuronic acid (glucuronic or iduronic acid).