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. Author manuscript; available in PMC: 2009 Feb 8.
Published in final edited form as: Brain Res. 2007 Dec 5;1193:34–42. doi: 10.1016/j.brainres.2007.11.045

Fig. 1.

Fig. 1

(A) Effects of repeated treatment with cocaine (10 mg/kg i.p.) or saline on locomotor activity in adolescent and adult DBA/2J mice. Cocaine-treated adolescent mice (Adol-Coc) displayed higher levels of locomotor activity on days 2 and 9 as compared with day 1 of treatment (*, p<0.05), indicating the development of behavioral sensitization. On day 9, Adol-Coc mice displayed increased locomotor activity as compared with Adult-Coc mice (+, p<0.05). Saline-treated adolescent (Adol-Sal) and adult mice (Adult-Sal) showed no changes in locomotor data across all days tested. Data are presented as mean ± SEM. N=18 for all groups. (B) Following recovery from surgical implantation of microdialysis guide cannula, a subsequent cocaine challenge (10 mg/kg i.p.) was given on Day 18 to cocaine-pretreated mice to assess the expression of behavioral sensitization. Cocaine-pretreated adolescent mice displayed greater locomotor activity in response to this cocaine challenge as compared with cocaine-pretreated adult mice (*, p<0.05). Data are presented as mean ± SEM.

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