Table 1.
Summary of the experimental schedule
| Day | 0 | 1–2 | 3–8 | 9 | 10–16 | 17 | 18 | 19 | 20 |
|---|---|---|---|---|---|---|---|---|---|
| Treat | |||||||||
| Sal | S | S | S | S | HC | Surgery | S | Probe impl | SC,C |
| Coc | S | C | C | C | HC | Surgery | C | Probe impl | SC,C |
| Activity | |||||||||
| Monitoring | Yes | Yes | Yes |
S, saline injections; C, cocaine injections; HC, home cage; Surgery, implantation of microdialysis guide cannula; Probe impl, implantation of microdialysis probe; SC, samples collection (4 samples prior cocaine injections-baselines-and 8 samples following cocaine injection). Locomotor activity was monitored on days 1, 2, 9 and 18.