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. Author manuscript; available in PMC: 2008 Apr 7.
Published in final edited form as: J Neurochem. 2007 Dec;103(5):1801–1810. doi: 10.1111/j.1471-4159.2007.04875.x

Fig. 7.

Fig. 7

Oral administration of fenofibrate inhibits CD14, MyD88, and TLR4 mRNA expression in experimental autoimmune encephalomyelitis mice. C57BL/6 mice were fed fenofibrate daily by gavage. Vehicle-treated mice were fed water containing 0.5% carboxymethyl-cellulose by gavage daily. Spinal cords were harvested on day 18 post-immunization, and total RNA was isolated. CD14 (a), MyD88 (b), and TLR4 (c) mRNA levels were quantified by real-time quantitative RT-PCR. Results are expressed as fold-changes relative to experimental autoimmune encephalomyelitis mice in vehicle group and all values are normalized against GAPDH. Values are mean ± SEM from five independent experiments, and duplicate reactions were performed on each sample in each experiment. *p < 0.05 and ***p < 0.001 versus vehicle-treated mice.