Figure 1.

Administration of APP^s₇₅₁ results in a significant improvement of discrimination performance (a) and reduces learning deficits induced by scopolamine (b) in a go-no go visual discrimination task. APP^s₇₅₁ (0.05 to 5,000 pg) was administered i.c.v. to mice either alone or after s.c. treatment with scopolamine (3 mg/kg). See text for details. The discrimination ratios of the different groups evolved significantly [a: F(2, 54) = 119.01, P < 0.001; b: F(2, 70) = 50.72, P < 0.001] and differently [treatment x session interaction—a: F(10, 54) = 2.17, P < 0.03; b: F(10, 70) = 2.44, P < 0.01] across the three daily sessions. Empty, hatched, and filled bars represent the first, second, and third sessions, respectively. ∗, P < 0.05 and ∗∗, P < 0.01, vs. saline; #, P < 0.05 and ##, P < 0.01, vs. scopolamine, Dunnett’s two-tailed t test.