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. 2008 Apr 8;118(5):1739–1749. doi: 10.1172/JCI33656

Figure 1. DNA copy-number aberrations in pediatric low-grade astrocytomas.

Figure 1

(A) Frequencies of DNA copy number gains and losses of tumors (n = 66) were plotted against their chromosomal position. (B) Complete array-CGH trace of a pilocytic astrocytoma, with a BRAF duplication at 7q34 representing the only detectable genomic aberration in this tumor. This constellation was found in 13 of 66 (20%) tumors (arrow indicates clones with copy number gain). (C) Array-CGH profile of chromosome 7 in another pilocytic astrocytoma with duplication of the BRAF locus at 7q34 (arrow indicates clones with copy number gain). (D) Duplication of the BRAF locus in a pilocytic astrocytoma as assessed by FISH. The probe covering the BRAF locus (3 copies) was labeled in green, and the centromeric control probe (2 copies) in red. Original magnification, ×100.