Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Apr 2;3(4):e1871. doi: 10.1371/journal.pone.0001871

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Gisselsson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A chromosome 12 specific alpha-satellite probe (green) combined with immunofluorescence for beta tubulin (red) and DNA-counterstaining by DAPI (blue) shows tetrasomic/bipolar cell division at metaphase/early anaphase (A) and late anaphase (B) and a disomic/tripolar cell division at metaphase (C) and telophase (D); the segregation pattern is 4-4 in (B) and 3-1-0 in (D). Time-lapse microscopy of H2B/GFP transfected HEK293 cells shows succession of a tripolar metaphase configuration (E; poles denoted a-c) through two successive chromosome segregation events to four daughter nuclei and from a tetrapolar metaphase configuration (F) through a tripolar ana-telophase to three daughter nuclei shown by three-dimensional reconstruction of a confocal image stack at T = 40 min (T, time from first image).