Table 2.
Effects of REV1 or REV3 deletion on spontaneous p53 mutant frequencies in different DNA repair backgrounds.
| DNA repair background | p53 mutant frequency ×1000 (red colonies/total) |
relative fold decrease |
statistics |
|---|---|---|---|
| WT | 0,91 | 1 | |
| (136/149.876)*§ | |||
| rev1 | 0,3 | 3.0 | |
| (25/83.195)* | *p<0.0001 | ||
| rev3 | 0,55 | 1.6 | |
| (74/134.023)§ |
|
§ p<0.0007 |
|
| rad14 | 1,18 | 1 | WT vs rad14: p<0.03 |
| (154/130.183) *§ | |||
| rad14rev1 | 0,61 | 1.9 | |
| (32/52.813) * | * p<0.0006 | ||
| rad14rev3 | 0,73 | 1.6 | |
| (39/53.562) § |
|
§ p<0.008 |
|
| mag1 | 0,7 | 1 | WT vs mag1: p<0.05 |
| (131/186.585) *§ | |||
| mag1rev1 | 0,58 | 1.2 | |
| (52/90.070) * | *NS | ||
| mag1rev3 | 0,83 | 0.84 | |
| (33/39.799) § |
|
§NS |
|
| apn1apn2 | 3,51 | 1 | WT vs apn1,apn2: p<0.0001 |
| (344/98.052) *§ | |||
| apn1apn2rev1 | 1,52 | 2.3 | |
| (50/32.798) * | * p<0.0001 | ||
| apn1apn2rev3 | 1,92 | 1.8 | |
| (51/26.521) § | § p<0.0001 |
NS: not significant