Table 3A.
Effects of REV1 or REV3 deletion on Me-lex induced p53 mutant frequencies in different DNA repair backgrounds (6mM Me-lex).
| DNA repair background | p53 MF ×1000 (red colonies/total) | relative fold decrease | statistics |
|---|---|---|---|
| WT | 7,0 | 1 | |
| (337/47.889)*§ | |||
| rev1 | 1,4 | 5,0 | |
| (28/19.660)*^ | *p<0.0001 | ||
| rev3 | 2,1 | 3,3 | |
| |
(51/24.300)§^ |
|
§ p<0.0001; ^NS |
| rad14 | 10.3 | 1 | WT vs rad14: p<0.0001 |
| (415/40.407) *§ | |||
| rad14 rev1 | 3,7 | 2,8 | |
| (36/9.820) *^ | * p<0.0001 | ||
| rad14rev3 | 3,2 | 3,2 | |
| |
(47/14.792) §^ |
|
§ p<0.0001; ^NS |
| mag1 | 12,7 | 1 | WT vs mag1: p<0.0001 |
| (259/20.458) *§ | |||
| mag1 rev1 | 4,1 | 3,1 | |
| (18/4.399) *^ | * p<0.0001 | ||
| mag1 rev3 | 4,2 | 2,5 | |
| |
(10/2.371) §^ |
|
§ p<0.0005; ^NS |
| apn1 apn2 | 60,1 | 1 | WT vs apn1,apn2: p<0.0001 |
| (510/8.488) *§ | |||
| apn1 apn2rev1 | 10,3 | 5,8 | |
| (14/1.355) *^ | * p<0.0001 | ||
| apn1 apn2rev3 | 8,2 | 7.3 | |
| (13/1.585) §^ | § p<0.0001; ^NS |
NS: not significant