Table 2.
Experimental condition | n | Baseline (mmHg ml−1 min) | Minimum (mmHg ml−1 min) | Plateau (% of response) | Maximum of 1st response (% of plateau) | Maximum of 2nd response (% of baseline) |
---|---|---|---|---|---|---|
Control | 8 | 0.38 ± 0.04 | 0.19 ± 0.02 | 35 ± 2 | 93 ± 3 | 119 ± 6 |
ACE inhibition | 8 | 0.27 ± 0.02 | 0.17 ± 0.01 | 31 ± 4 | 91 ± 2 | 103 ± 2* |
Control | 8 | 0.29 ± 0.03 | 0.15 ± 0.02 | 45 ± 2 | 98 ± 2 | 120 ± 5 |
ACE inhibition + ANGII | 8 | 0.48 ± 0.04*† | 0.16 ± 0.02 | 51 ± 4† | 105 ± 3† | 139 ± 17 |
Baseline refers to renal vascular resistance (RVR) before the pressure reduction. Minimum refers to RVR immediately after pressure release. Plateau refers to RVR during the plateau expressed as a percentage of the total response between baseline and minimum. Maximum of the first response refers to the maximum RVR detected 2.5–10 s after release of the RAP reduction, expressed as a percentage of the level of the plateau. Maximum of the second response refers to the maximum RVR detected 25–80 s after pressure release, expressed as a percentage of baseline. Data are mean ± s.e.m.n, number of animals.
P < 0.05 vs. paired control.
P < 0.05 vs. ACE inhibition alone.