Representative currents elicited in response to voltage steps from −100 to +100 mV (increment 20 mV) obtained from non-stimulated human skin fibroblasts. A, basal conditions. B, after increasing the extracellular K+ concentration from 5 to 25 mm. C, after applying 1 mm TEA. D, I–V curves for the three conditions described: basal (•), after increasing extracellular K+ to 25 mm (□) and after addition of 1 mm TEA (▵). Representative traces are shown from one cell (n = 4). Arrows indicate zero current level. Holding potential, Vh = 0 mV.