Table 4.
Basic physiological and MRI-myocardial volumes of the captopril-treated group diabetic from 7 weeks
| Parameter | Value | P |
|---|---|---|
| Body weight at disease induction (g) | 260 ± 10.6 † | NA |
| Body weight at scanning time (g) | 247.5 ± 15.5* | < 0.001 |
| Blood glucose (mm) | 29.4 ± 1.2* | < 0.001 |
| Systolic blood pressure (mmHg) | 137.5 ± 7.5 ‡ | 0.006 |
| Heart rate (beats min−1) | 311 ± 10 | 0.017 |
| Left ventricular weight (g) | 0.463 ± 0.02*‡ | < 0.001 |
| Right ventricular weight (g) | 0.148 ± 0.008*‡ | < 0.001 |
| LVMV (μl) | 448.8 ± 20.1*‡ | < 0.001 |
| RVMV (μl) | 147± 11.9* | 0.004 |
| Left ventricular weight/body weight (%) | 0.188 ± 0.009 ‡ | < 0.001 |
| Right ventricular weight/body weight (%) | 0.06 ± 0.0005 ‡ | < 0.001 |
| LVMV/ body weight (μl g−1) | 1.82 ± 0.05 ‡ | < 0.001 |
| RVMV/ body weight (μl g−1) | 0.59 ± 0.01 ‡ | < 0.001 |
LVMV, left ventricular myocardial volume; RVMV, right ventricular myocardial volume. NA, not applicable. All values are expressed as means ±s.e.m. One-way ANOVA was used to compare the control and the two groups made diabetic from 7 weeks (one group not treated with captopril and the other treated with captopril; n = 4 animals in each group) followed by Tukey's honestly significant difference test for pairwise multiple comparisons. The body weight-normalized values were calculated using the corresponding body weight of the anaesthetized rat. A value of P < 0.05 was considered significant.
Significantly different from the control group.
Significantly different from the similarly diabetic group spared captopril treatment.
Within accepted range of standard Wistar rat growth curves.