Table 4.

Preconditioning either with heat or geldanamycin attenuates lung endothelial permeability to protein after haemorrhagic shock

Experimental condition	n	Extravascular PE (ml)
No preconditioning
Controls — no shock	6	0.07 ± 0.01
Controls + alveolar adrenaline	3	0.08 ± 0.01
Haemorrhagic shock	6	0.30 ± 0.08*
Haemorrhagic shock + alveolar adrenaline	5	0.28 ± 0.07*
Stress preconditioning with heat
Controls + alveolar adrenaline	4	0.06 ± 0.02
Haemorrhagic shock + alveolar adrenaline	5	0.10 ± 0.03
Stress preconditioning with geldanamycin
Controls + alveolar adrenaline	4	0.07 ± 0.03
Haemorrhagic shock + alveolar adrenaline	4	0.11 ± 0.02

Data are given as means ± s.e.m. Extravascular PE, extravascular plasma equivalents.

^*P < 0.05 from controls. Lung endothelial permeability to protein was measured as accumulation of the vascular tracer ¹³¹I-labelled albumin inextravascular spaces of the non-instilled lung, and was expressed as extravascular plasma equivalents.