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. 2002 Jan 15;538(Pt 2):555–572. doi: 10.1113/jphysiol.2001.012857

Table 5.

Derived left ventricular indices of control and the three diabetic groups spared captopril treatment

Diabetic
Control 3 week 6 week 9 week P
Left ventricular output (LVOP) (l min−1) 0.102 ± 0.003b, c, d 0.090 ± 0.003a, c, d 0.050 ± 0.001a, b, d 0.033 ± 0.002a, b, c <0.001
LVOP/body weight (l min−1 kg−1) 0.291 ± 0.001b, c, d 0.269 ± 0.005a, c, d 0.176 ± 0.005a, b, d 0.142 ± 0.007a, b, c <0.001
LVOP/heart weight (l min−1 g−1) 0.12 ± 0.002b, c, d 0.11 ± 0.002a, c, d 0.06 ± 0.002a, b, d 0.05 ± 0.002a, b, c <0.001
MLVP (W) 0.033 ± 0.002c, d 0.027 ± 0.001c, d 0.012 ± 0.001a, b 0.007 ± 0.001a, b <0.001
MLVP/body weight (mW g−1) 0.093 ± 0.004c, d 0.082 ± 0.005c, d 0.044 ± 0.004a, b 0.030 ± 0.004a, b <0.001
MLVP/Heart weight (W g−1) 0.037 ± 0.002c, d 0.032 ± 0.002c, d 0.016 ± 0.001a, b 0.010 ± 0.001a, b <0.001
MLVSW (J) 0.006 ± 0.0003b, c, d 0.005 ± 0.0002a, c, d 0.003 ± 0.0001a, b, d 0.001 ± 0.0001a, b, c <0.001
MLVSW/body weight (mJ g−1) 0.017 ± 0.0005c, d 0.016 ± 0.0009c, d 0.009 ± 0.0006a, b, d 0.006 ± 0.0007a, b, c <0.001
MLVSW/heart weight (J g−1) 0.007 ± 0.0002c, d 0.006 ± 0.0003c, d 0.003 ± 0.0002a, b, d 0.002 ± 0.0003a, b, c <0.001
Left ventricular systolic elastance (mmHg μl−1) 0.82 ± 0.03 0.78 ± 0.06 0.63 ± 0.06 0.57 ± 0.09 0.05
LVMV (μl)/LVEDV (μl) 1.32 ± 0.02c, d 1.38 ± 0.01c, d 1.68 ± 0.03a, b, d 1.88 ± 0.01a, b, c <0.001
RVMV (μl)/RVEDV (μl) 0.43 ± 0.012c, d 0.45 ± 0.007c, d 0.50 ± 0.008a, b, d 0.62 ± 0.009a, b, c <0.001

MLVP, maximum left ventricular power; MLVSW, maximum left ventricular stroke work; MV, myocardial volume. All values expressed as means ± s.e.m.; n = 4. One-way ANOVA was used in comparison of the control and the three untreated diabetic groups followed by Tukey's Honestly Significant Difference test for pair-wise multiple comparisons. A value of P <0.05 was considered statistically significant. RVMV/RVEDV included for comparison with the corresponding left ventricular parameter.

a

Significantly different from the control group.

b

Significantly different from the 3-week diabetic group.

c

Significantly different from the 6-week diabetic group.

d

Significantly different from the 9-week untreated diabetic group.