Table 2.

Gating parameters of the sodium channel constructs tested

Isoform	Cell	n	Va (mV)	Ka (mV)	Vi (mV)	Ki (mV)	th (at −40 mV) (ms)	trec (at −100 mV) (ms)
hSkM1	Pro5	9	−31.26 ± 1.99	7.35 ± 0.30	−71.45 ± 3.26	−5.94 ± 0.29	2.36 ± 0.41	3.62 ± 0.03
	Lec2	9	−16.73 ± 1.72**	8.68 ± 0.61*	−60.83 ± 1.54**	−6.50 ± 0.32	7.93 ± 1.06**	2.21 ± 0.03**
hH1	Pro5	13	−28.99 ± 2.19	9.14 ± 0.47	−78.68 ± 2.53	−7.53 ± 0.60	2.80 ± 0.44	6.39 ± 0.18
	Lec2	10	−29.48 ± 1.59	9.07 ± 0.47	−79.54 ± 1.92	−8.32 ± 0.53	2.43 ± 0.24	6.80 ± 0.31
hSkM1P1	Pro5	10	−23.51 ± 2.32	8.46 ± 0.37	−70.41 ± 2.51	−6.63 ± 0.29	3.43 ± 0.52	3.38 ± 0.13
	Lec2	8	−26.73 ± 1.23	7.87 ± 0.30	−68.79 ± 2.47	−6.43 ± 0.29	3.43 ± 0.76	3.77 ± 0.24
hH1P1	Pro5	9	−29.01 ± 1.34	8.29 ± 0.49	−74.90 ± 3.33	−6.40 ± 0.73	3.62 ± 0.20	5.63 ± 0.24
	Lec2	9	−22.44 ± 1.08**	8.46 ± 0.54	−69.35 ± 3.60	−7.67 ± 0.58	5.91 ± 0.31**	4.33 ± 0.15**

Data list the mean parameter value ± s.e.m. for six gating parameters measured for hSkM1, hH1, hSkM1P1,and hH1P1 as expressed in Pro5 and Lec2 cells. Significance was tested throughout using a two-tailed test.

^*Significant (P < 0.01)

^**highly significant (P < 0.005).