Figure 2. Normalized current-voltage relationships of hH1 (A) and μ1 (B) channels in 0 mm external sodium.

The channels were modified by perfusing the cells with external solution containing 100 μm AC and delivering ≥ 50 depolarizing pulses to +20 mV. The currents in the insets are from representative experiments. Scale, 1 nA, 2 ms. A, current-voltage relationship of hH1 channels before (▪, n = 13) and after (□, n = 11) AC modification. B, current-voltage relationship of μ1 channels before (•, n = 6) and after (○, n = 6) AC modification. AC modification shifted the voltage dependence of current activation of both channel isoforms by −15 to −20 mV.