Figure 6. AC modification of hH1 (▪, □, ▴, ▵) and μ1 (•, ○) does not affect the voltage dependence of macroscopic current decay in external solution containing 130 mm sodium.
The decay of hH1 current was often best fitted by the sum of two exponentials: y = A1exp(-t/τ1) + A2exp(-t/τ2); the triangles in the plot correspond to the slow time constant of hH1 inactivation. The decay of μ1 current was best fit by a single exponential: y = A1exp(-t/τ1). The decay of macroscopic currents was measured before (filled symbols) and after (open symbols) modification of the channels by 100 μm AC. The traces in the inset are from a representative experiment on hH1 channels. The dashed line in the lower set of traces denotes the baseline current level. Scale, 2 ms.