Table 2.
Unidirectional and net fluxes of Na+ and Cl− across distal colon of hyperaldosteronaemic rats:effect of amiloride and butyrate
| G | ISC | JNa,ms | JNa,sm | JNa,net | JCl,ms | JCl,sm | JCl,net | |
|---|---|---|---|---|---|---|---|---|
| Control | ||||||||
| Basal | 8.3±0.4 | 2.4± 0.2 | 7.6 ± 0.8 | 4.2 ± 0.7 | 3.4 ±0.3 | 4.8 ± 0.6 | 5.0 ± 0.5 | −0.2 ± 0.2 |
| Amiloride | 8.7 ± 0.4§ | 0.4 ±0.1§ | 5.2 ±0.9* | 5.0 ± 1.0n.s. | 0.2 ± 0.2§ | 5.9 ± 0.3§ | 5.8 ± 0.3n.s. | 0.1 ± 0.1n.s. |
| Butyrate | ||||||||
| Basal | 9.6 ± 0.5n.s. | 1.7 ± 0.3n.s. | 9.6 ± 0.5* | 3.7 ± 0.4n.s. | 5.9 ± 0.2§ | 6.1 ± 0.4n.s. | 4.0 ± 0.3n.s. | 2.1 ± 0.3§ |
| Amiloride | 11.1 ± 0.5§ | 0.1 ±0.2† | 8.0 ± 0.8n.s. | 5.4 ± 0.7n.s. | 2.7 ± 0.4§ | 7.0 ±0.8n.s. | 4.1 ± 0.5n.s. | 2.9 ± 0.5n.s. |
for both control and butyrate studies,the values shown are means ±s.e.m. of eight tissue pairs. Amiloride was always added to the mucosal bath solution after three 15 min flux periods. See Table 1 for further details and definitions.