Table 2.
Effect of Cl−channel blockers on the kinetic properties of ICl(Ca) activated by 500nm[Ca2+]i involtagejumpexperiments in rabbit pulmonary artery smooth muscle cells
| +70 mV | −80 mV | |||||||
|---|---|---|---|---|---|---|---|---|
| IinstA+70(pA) | (n) | Irelax+70(pA) | (n) | Iinst−80(pA) | (n) | Irelax−80(pA) | (n) | |
| DCDPC (100 μm) | ||||||||
| Control | 117 ± 12 | (14) | 89 ± 12 | (14) | 368 ± 39 | (14) | 144 ± 16 | (14) |
| +DCDPC | 138 ± 15 | (14) | 12 ± 4 | (14)* | 209 ± 23 | (14)* | 14 ± 2 | (14)* |
| Wash | 370 ± 38 | (10)* | 26 ± 5 | (10)* | 543 ± 49 | (10)* | 40 ± 9 | (10)* |
| DIDS (1mm) | ||||||||
| Control | 188 ± 39 | (5) | 90 ± 31 | (5) | 449 ± 49 | (5) | 139 ± 31 | (5) |
| +DIDS | 137 ± 27 | (5)* | 13 ± 6 | (5)* | 272 ± 67 | (5)* | 84 ± 40 | (5)* |
| Wash | 133 ± 25 | (4) | 56 ± 13 | (4) | 350 ± 64 | (4) | 140 ± 25 | (4) |
Values in parentheses indicate number of cells.
*
Indicates significant difference (P < 0.05) from control as determined by Student's paired t test.