Table 1.
Effects of a depolarizing conditioning step on PGE2 modulation of HVA/Ca in mouse trigeminal neurons
| n | Control | 1 μm PGE2 | n | Control | 30 μm Baclofen | |
|---|---|---|---|---|---|---|
| Type 1 | ||||||
| Ratio S2:S1 peak amplitude | 7 | 1.01 ± 0.07 | 1.19 ±0.09* | 9 | 1.00 ± 0.05 | 1.18 ± 0.07*** |
| 0–50% rise time of S1 (ms) | 7 | 0.95 ± 0.07 | 1.11 ± 0.05* | 9 | 1.18 ±0.07 | 1.29 ± 0.10* |
| 0–50% rise time of S2 (ms) | 7 | 1.02 ± 0.08 | 1.05 ±0.08 | 9 | 1.11 ±0.05 | 1.14 ± 0.06 |
| Type 2 | ||||||
| Ratio S2:S1 peak amplitude | 8 | 1.07 ± 0.07 | 1.36 ± 0.09*** | |||
| 0–50% rise time of S1 (ms) | 8 | 1.69 ±0.08 | 2.35 ±0.17* | |||
| 0–50% rise time of S2 (ms) | 8 | 1.60 ±0.15 | 1.86 ± 0.18† | |||
Values are means and s.e.m. The S1:S2 ratio and 0–50% rise times were significantly greater than controls on indicated values (Student's paired, two tailed t test)
*
P < 0.05
***
P < 0.001.
†
Significantly different from S1 in PGE2, Student's unpaired t test,P <0.02.