Skip to main content
. 2002 Mar 1;539(Pt 2):567–578. doi: 10.1113/jphysiol.2001.013283

Figure 8. Robust whisker-evoked IPSPs can restrict the ability of postsynaptic depolarization to eliminate thalamic sensory suppression.

Figure 8

A, intracellular recording from a VPM neuron that responds to whisker stimulation with an EPSP followed by a robust IPSP. Both the EPSPs and IPSPs depress with repetition at 10 Hz (right panel). B, when sensory-evoked IPSPs are very robust, postsynaptic depolarization is not effective in eliminating thalamic suppression during the initial stimulus trials when inhibition has not yet depressed. Notice that at resting potential (0 DC) the cell only produces an action potential to the first stimulus, and despite strong depression of IPSPs there is no relay of sensory inputs during the latter stimuli. As the neuron is depolarized from resting the latter stimuli are able to relay the sensory input, but the initial stimuli are not capable because of the strong sensory-evoked IPSPs. Whisker stimulation consisted of 15 stimuli at 10 Hz. Action potentials are truncated.