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. 2002 Mar 15;539(Pt 3):707–712. doi: 10.1113/jphysiol.2001.015024

Figure 3. Excitatory connections between nearby layer 3 pyramidal neurons are unaffected by addition of DA.

Figure 3

A, left, schematic showing recording configuration. Two pyramidal neurons with somata less than 50 μm apart were recorded simultaneously. Right, activation of an action potential in one cell evoked a unitary EPSP in the other. Traces show average pre- and postsynaptic responses from 10 consecutive sweeps recorded under control conditions (black line - a) or in the presence of dopamine (5 μm, grey line - b). B, time course of the DA effect. The amplitude of each unitary EPSP is plotted as a function of time from whole cell break-in. DA had no observable effect on EPSP amplitude at this unitary connection. Markings (a) and (b) show the time at which example traces in A were recorded. C, histogram showing amplitudes of the unitary EPSPs recorded in control conditions and in the presence of DA. D, group data showing effect of DA application on unitary EPSPs.