Table 1.
Effects of fKChIP2 isoforms on fKv4.3 gating parameters and comparison to native LV epicardial myocytes
| Xenopus oocytes | |||||
|---|---|---|---|---|---|
| fKv4.3 | fKv4.3 + fKChIP2 | fKv4.3 + fKChIP2a | fKv4.3 + fKChIP2b | LV epicardial myocytes * | |
| V½,act (mV) | −9.8 (7) | −11.5 (7) | 6.3 (7) | −6.6 (8) | 22.5 |
| τ1, inact,+50mV (ms) | 67.0 ± 4.6 (6) | 148.6 ± 5.9 (7) | 153.6 ± 3.3 (5) | 139.2 ± 3.8 (7) | 75.7 ± 4.8 |
| τ2, inact,+50mV (ms) | 489.4 ± 5.3 (6) | — | — | — | — |
| % τ1,inact | 0.808 ± 0.007 (6) | — | — | — | — |
| V½,inact (mV) | −53.8 (7) | −49.0 (7) | −34.7 (8) | −47.7 (8) | −9 |
| kinact (mV) | 5.5 (7) | 4.8 (7) | 4.8 (8) | 4.9 (8) | 5.45 |
| τrec,−100 mV (ms) | 229.2 ± 2.4 (7) | 54.6 ± 0.6 (6) | 60.8 ± 0.6 (6) | 63.3 ± 0.4 (8) | 51.2 ± 2.6 † |
*
LV epicardial myocyte data from Brahmajothi et al. (1999).
†
−70mV. Values of n are given in parentheses.