Table 1.
Baseline data
| Control mice | Anti-VIP mice | ||||
|---|---|---|---|---|---|
| Male | Female | Male | Female | P (ANOVA) | |
| n | 14 | 8 | 11 | 10 | — |
| Body weight (g) | 29 ± 4 | 24 ± 2 | 26 ± 5 | 23 ± 3 | 0.0006 |
| Delay to sleep onset (min) | 75 ± 35 | 113 ± 34 | 70 ± 23 | 91 ± 30 | 0.003 |
| TI (ms) | 169 ± 17 | 187 ± 19 | 181 ± 31 | 178 ± 32 | 0.37 |
| TTOT (ms) | 362 ± 33 | 381 ± 36 | 377 ± 43 | 367 ± 61 | 0.76 |
| VT (μl g−1) | 5.9 ± 1 | 7.3 ± 0.5 | 5.8 ± 0.6 | 6.6 ± 0.7 | 0.001 |
| V̇E (μl s−1 g−1) | 17 ± 3 | 20 ± 3 | 16 ± 3 | 19 ± 3 | 0.004 |
The number of mice studied (n), together with body weights and the delay to sleep onset (first period of ≥ 3 min continuous QS) are indicated. Baseline ventilation in air (phase 1) is also shown. TI and TTOT, inspiratory and total breath times, respectively; VT and V̇E, tidal volume and minute ventilation, respectively. Significant gender differences are indicated in the final column; treatment group values are not significantly different from control values. Data are means ±s.d.