Figure 2. Effects of GABA_B receptor blockade on burst frequency at different ages.

A and B, examples of age-dependent effects of CGP (40 nm) on burst discharge frequency in P1 (A) and P9 (B) slice preparations. C, bar graph summarising the concentration-dependent effects of CGP in P0-P3 (open bars, n = 10) and P7-P15 (filled bars, n = 14) slice preparations. The threshold concentration of CGP was 20 nm in P0-P3 preparations and 5 nm in P7-P15 preparations. D, plot showing reversal of the CGP (40 nm) effect from excitatory to depressant over days P4-P6. Each symbol represents one experiment carried out on one individual slice obtained from a mouse at the indicated age.