Figure 7. Modulation of hypertonic induction of BGT1 and SMIT transport activities induced by hypertonicity.
The initial rates of uptake of GABA and myo-inositol (extracellular concentrations 0.1 mmol l−1) by endothelial cells were measured after the cells had been incubated for the indicated times in depleted hypertonic (0.5 osmol (kg H2O)−1) medium with or without added betaine and myo-inositol, each at 0.1 mmol l−1. Sucrose was used as the extra osmolyte. Mean values (±s.d.) of four measurements are given. Open symbols, depleted of compatible osmolytes; filled symbols, with betaine and myo-inositol; ▴, GABA; •, myo-inositol.