Table 3.
Effects of imposed flow and the nitric oxide synthase inhibitor L-NMMA (10 μm) on active lymph pump parameters in rat mesenteric lymphatics
| Imposed flow (cmH2O) | Treatment | DD % | SD % | CF % | EF | FPF (min−1) |
|---|---|---|---|---|---|---|
| 0 | Control | 88 ± 1 | 56 ± 4 | 100 ± 0 | 0.59 ± 0.05 | 5.1 ± 0.7 |
| 0 | l-NMMA | 87 ± 2 | 54 ± 2 | 107 ± 14 | 0.61 ± 0.03 | 5.7 ± 0.4 |
| 3 | Control | 90 ± 2 | 76 ± 6 | 44 ± 16 | 0.26 ± 0.11 | 1.9 ± 0.9 |
| 3 | l-NMMA | 88 ± 2 | 67 ± 5 * | 66 ± 14 * | 0.40 ± 0.08 * | 2.4 ± 0.6 |
| 7 | Control | 91 ± 1 | 79 ± 5 | 30 ± 11 | 0.22 ± 0.09 | 1.0 ± 0.5 |
| 7 | l-NMMA | 91 ± 2 | 72 ± 4 * | 44 ± 9 * | 0.35 ± 0.08 * | 1.6 ± 0.5 |
Values are means ±s.e.m. SD, normalized systolic diameter; DD, normalized diastolic diameter; CF, normalized contraction frequency; EF, ejection fraction; FPF, fractional pump flow. (Diameters are normalized to the passive diameter at 0 cmH2O pressure gradient condition; contraction frequencies are normalized to the 0 cmH2O pressure gradient condition.)
*
Significantly different from control (P < 0.05, n = 7).