Figure 7. Effects of pre-pulses on the slowly activating and rapidly activating delayed rectifier currents (I_Ks and I_Kr, respectively) during AP repolarization, calculated using a theoretical model of a mammalian AP.

A, effects of pre-pulses on the AP reconstituted using the model calculation. A depolarizing (−2.7 A F⁻¹, 50 ms) or a hyperpolarizing (16 A F⁻¹, 50 ms) current was added before the stimulating current (I_stim) was applied. B, I_Ks and I_Kr plotted against V_m during the repolarization phase of the reconstituted APs. The continuous line, control; dashed line, with a depolarizing pre-pulse; dotted line, with a hyperpolarizing pre-pulse.